2-Hydroxyoleic acid affects cardiomyocyte [Ca ]i transient and contractility in a region-dependent manner
نویسندگان
چکیده
Gudrun H. Borchert, Mike Giggey, Frantisek Kolar, Tak Ming Wong, Peter H. Backx, and Pablo V. Escriba Laboratory of Molecular and Cellular Biomedicine, University of the Balearic Islands, Palma de Mallorca, Spain; Institute of Physiology, Academy of Sciences of the Czech Republic and Centre for Cardiovascular Research, Prague, Czech Republic; Department of Physiology and Medicine, University of Toronto, Heart and Stroke/Richard-Lewar-Centre of Excellence, Toronto, Canada; and Department of Physiology, The University of Hong Kong, Hong Kong, China
منابع مشابه
2-hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner.
Monounsaturated fatty acids such as oleic acid are cardioprotective, modify the physicochemical properties of cardiomyocyte membranes, and affect the electrical stability of these cells by regulating the conductance of ion channels. We have designed a nonhydrolysable oleic acid derivative, 2-hydroxyoleic acid (2-OHOA), which regulates membrane lipid structure and cell signaling, resulting in be...
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تاریخ انتشار 2008